Formulation · 4 min read

The Role of Excipients in Peptide Stability

An excipient is any pharmacologically inactive ingredient that accompanies the active compound in a formulation. In the context of peptide research, excipients are indispensable during lyophilization (freeze-drying) and subsequent reconstitution, shielding the peptide from degradation, aggregation, and conformational damage throughout processing and storage.

Multiple categories of excipients have been characterized for their capacity to protect peptides during the freeze-drying process:

The scientific literature describes two principal mechanisms by which excipients safeguard peptides during lyophilization:

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