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From the published research
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis.
In research models, MOTS-c has been observed to act as a retrograde signalling molecule from the mitochondrial genome to the nucleus. Studies suggest it activates AMPK, improves insulin sensitivity via GLUT4 translocation, enhances fatty acid oxidation, and regulates the folate-methionine cycle. It represents a direct communication pathway between mitochondria and nuclear gene expression. Areas of research interest include: AMPK metabolic master switch activation studied in research; Insulin sensitivity and glucose utilization effects investigated; Fat oxidation and metabolic flexibility effects studied.
Is MOTS-c third-party tested?
Yes. Each batch of MOTS-c is analyzed by an independent third-party laboratory. Batch MOT01 (results dated March 5, 2026) reported average purity of 98.94% and average mass of 10.11 mg. Full Certificate of Analysis documentation is available for this product.
What does published research say about MOTS-c?
Discovered at USC in 2015, MOTS-c research has expanded rapidly. Published studies demonstrate effects on insulin sensitivity, exercise capacity, and protection against metabolic dysfunction. Animal studies show lifespan extension and prevention of age-related metabolic decline. This page cites 1 published reference for further reading.
Who typically studies MOTS-c in a laboratory setting?
This peptide is supplied as a lyophilized (freeze-dried) powder. Bacteriostatic water is required to reconstitute it before use and is not included with this product. Store lyophilized (powder) form at -20°C for long-term or refrigerated (2-8°C) for short-term. After reconstitution, store refrigerated and use within 21 days.
Where can I buy MOTS-c in Canada?
MyPeptide is a Canadian supplier of research peptides based in Mississauga, Ontario. MOTS-c is stocked domestically and ships to research customers nationwide — including Toronto, Vancouver, Calgary, Edmonton, Ottawa, and Montreal. Every order includes third-party Certificate of Analysis documentation for the batch shipped.
Does MyPeptide ship MOTS-c across Canada?
Yes. MOTS-c ships from within Canada to every province and territory, with fast domestic delivery and no international customs delays. Orders are dispatched with tracking, and all products are sold strictly for laboratory and research use only.
Research peptide reference page
MOTS-c
A mitochondrial-derived peptide studied in research as a metabolic regulator. Investigated for effects on insulin sensitivity, fat metabolism, and exercise capacity while demonstrating cellular aging effects.
CAS number: 1627580-64-6.
In research models, MOTS-c has been observed to act as a retrograde signalling molecule from the mitochondrial genome to the nucleus. Studies suggest it activates AMPK, improves insulin sensitivity via GLUT4 translocation, enhances fatty acid oxidation, and regulates the folate-methionine cycle. It represents a direct communication pathway between mitochondria and nuclear gene expression.
MOTS-c is supplied for laboratory research use only. It is not for human or animal use, clinical use, diagnostic use, therapeutic use, or personal-use protocols.
Each MyPeptide reference page is organized around product identity, documentation, and research context rather than medical claims, dosing instructions, or personal-use outcomes.
Use the related links on this page to move between the catalog, COA records, policy pages, and supporting research guides while staying within the research-use-only scope.
Batch documentation, product identity, and compliance context are kept close together so qualified purchasers can review the material before continuing through the storefront.
Research context
Discovered at USC in 2015, MOTS-c research has expanded rapidly. Published studies demonstrate effects on insulin sensitivity, exercise capacity, and protection against metabolic dysfunction. Animal studies show lifespan extension and prevention of age-related metabolic decline.
Store lyophilized (powder) form at -20°C for long-term or refrigerated (2-8°C) for short-term. After reconstitution, store refrigerated and use within 21 days.
